6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer

Metastasis is the cause of death in the majority (~90%) of malignant cancers. The oral potassium-sparing diuretic amiloride and its 5-substituted derivative 5-N,N-(hexamethylene)amiloride (HMA) reportedly show robust antitumor/ metastasis effects in multiple in vitro and animal models. These effects...

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Foilsithe in:J Med Chem
Main Authors: Buckley, Benjamin J., Aboelela, Ashraf, Minaei, Elahe, Jiang, Longguang X., Xu, Zhihong, Ali, Umar, Fildes, Karen, Cheung, Chen-Yi, Cook, Simon M., Johnson, Darren C., Bachovchin, Daniel A., Cook, Gregory M., Apte, Minoti, Huang, Mingdong, Ranson, Marie, Kelso, Michael J.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2018
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6290913/
https://ncbi.nlm.nih.gov/pubmed/30130401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b00838
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