6-Substituted amiloride derivatives as inhibitors of the urokinase-type plasminogen activator for use in metastatic disease

The oral K+-sparing diuretic amiloride shows anti-cancer side-activities in multiple rodent models. These effects appear to arise, at least in part, through moderate inhibition of the urokinase-type plasminogen activator (uPA, K(i) = 2.4 μM), a pro-metastatic trypsin-like serine protease that is upr...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem Lett
Main Authors: Buckley, Benjamin J., Majed, Hiwa, Aboelela, Ashraf, Minaei, Elahe, Jiang, Longguang, Fildes, Karen, Cheung, Chen-Yi, Johnson, Darren, Bachovchin, Daniel, Cook, Gregory M., Huang, Mingdong, Ranson, Marie, Kelso, Michael J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7362394/
https://ncbi.nlm.nih.gov/pubmed/31679971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2019.126753
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