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6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer

Metastasis is the cause of death in the majority (~90%) of malignant cancers. The oral potassium-sparing diuretic amiloride and its 5-substituted derivative 5-N,N-(hexamethylene)amiloride (HMA) reportedly show robust antitumor/ metastasis effects in multiple in vitro and animal models. These effects...

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Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:	J Med Chem
Κύριοι συγγραφείς:	Buckley, Benjamin J., Aboelela, Ashraf, Minaei, Elahe, Jiang, Longguang X., Xu, Zhihong, Ali, Umar, Fildes, Karen, Cheung, Chen-Yi, Cook, Simon M., Johnson, Darren C., Bachovchin, Daniel A., Cook, Gregory M., Apte, Minoti, Huang, Mingdong, Ranson, Marie, Kelso, Michael J.
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	2018
Θέματα:	Article
Διαθέσιμο Online:	https://ncbi.nlm.nih.gov/pmc/articles/PMC6290913/ https://ncbi.nlm.nih.gov/pubmed/30130401 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b00838
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6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer

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