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Renal Excretion of Recombinant Immunotoxins Containing Pseudomonas Exotoxin

Recombinant immunotoxins BL22 (CAT-3888) and LMB-2, composed of Fv fragments of anti-CD22 and CD25 MAbs, respectively, have produced major responses in patients with hematologic malignancies, and are also associated with renal toxicity, particularly with BL22. Characterization of the renal excretion...

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Publicado en:Bioconjug Chem
Main Authors: Traini, Roberta, Kreitman, Robert J
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6290476/
https://ncbi.nlm.nih.gov/pubmed/21410247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc1005152
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