The structures of penicillin-binding protein 4 (PBP4) and PBP5 from Enterococci provide structural insights into β-lactam resistance

The final steps of cell-wall biosynthesis in bacteria are carried out by penicillin-binding proteins (PBPs), whose transpeptidase domains form the cross-links in peptidoglycan chains that define the bacterial cell wall. These enzymes are the targets of β-lactam antibiotics, as their inhibition reduc...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:J Biol Chem
Päätekijät: Moon, Thomas M., D'Andréa, Éverton D., Lee, Christopher W., Soares, Alexei, Jakoncic, Jean, Desbonnet, Charlene, Garcia-Solache, Monica, Rice, Lou B., Page, Rebecca, Peti, Wolfgang
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2018
Aiheet:
Enzymology
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6290140/
https://ncbi.nlm.nih.gov/pubmed/30355734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006052
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