High-Level Resistance of Staphylococcus aureus to β-Lactam Antibiotics Mediated by Penicillin-Binding Protein 4 (PBP4)

Penicillin-binding protein 4 (PBP4), a nonessential, low-molecular-weight penicillin-binding protein of Staphylococcus aureus, has been implicated in low-level resistance to β-lactam antibiotics, although the mechanism is unknown. Mutations in PBP4 and its promoter were identified in a laboratory-ge...

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Foilsithe in:Antimicrob Agents Chemother
Main Authors: Hamilton, Stephanie M., Alexander, J. Andrew N., Choo, Eun Ju, Basuino, Li, da Costa, Thaina M., Severin, Anatoly, Chung, Marilyn, Aedo, Sandra, Strynadka, Natalie C. J., Tomasz, Alexander, Chatterjee, Som S., Chambers, Henry F.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology 2017
Ábhair:
Mechanisms of Resistance
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5444179/
https://ncbi.nlm.nih.gov/pubmed/28373193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02727-16
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