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High-Level Resistance of Staphylococcus aureus to β-Lactam Antibiotics Mediated by Penicillin-Binding Protein 4 (PBP4)

Penicillin-binding protein 4 (PBP4), a nonessential, low-molecular-weight penicillin-binding protein of Staphylococcus aureus, has been implicated in low-level resistance to β-lactam antibiotics, although the mechanism is unknown. Mutations in PBP4 and its promoter were identified in a laboratory-ge...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Hamilton, Stephanie M., Alexander, J. Andrew N., Choo, Eun Ju, Basuino, Li, da Costa, Thaina M., Severin, Anatoly, Chung, Marilyn, Aedo, Sandra, Strynadka, Natalie C. J., Tomasz, Alexander, Chatterjee, Som S., Chambers, Henry F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5444179/
https://ncbi.nlm.nih.gov/pubmed/28373193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02727-16
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