PBP4 Mediates β-Lactam Resistance by Altered Function

Penicillin binding protein 4 (PBP4) can provide high-level β-lactam resistance in Staphylococcus aureus. A series of missense and promoter mutations associated with pbp4 were detected in strains that displayed high-level resistance. We show here that the missense mutations facilitate the β-lactam re...

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Veröffentlicht in:Antimicrob Agents Chemother
Hauptverfasser: Chatterjee, Som S., Chen, Liang, Gilbert, Aubre, da Costa, Thaina M., Nair, Vinod, Datta, Sandip K., Kreiswirth, Barry N., Chambers, Henry F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2017
Schlagworte:
Mechanisms of Resistance
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5655059/
https://ncbi.nlm.nih.gov/pubmed/28807923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00932-17
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