Non-redundant roles of IL-21 and IL-4 in the phased initiation of germinal center B cells and subsequent self-renewal transitions

We examined the unique contributions of the cytokines IL-21 and IL-4 on germinal center (GC) B cell initiation and subsequent maturation in a murine model system. Similar to other reports, we found T follicular helper cell (Tfh) expression of IL-21 begins prior to Tfh migration into the B cell folli...

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Pubblicato in:J Immunol
Autori principali: Gonzalez, David G., Cote, Christine M., Patel, Jaymin R., Smith, Colin B., Zhang, Yuqi, Nickerson, Kevin M., Zhang, Tingting, Kerfoot, Steven M., Haberman, Ann M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6289626/
https://ncbi.nlm.nih.gov/pubmed/30446568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1500497
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