IL-21 regulates germinal center B cell differentiation and proliferation through a B cell–intrinsic mechanism

Germinal centers (GCs) are sites of B cell proliferation, somatic hypermutation, and selection of variants with improved affinity for antigen. Long-lived memory B cells and plasma cells are also generated in GCs, although how B cell differentiation in GCs is regulated is unclear. IL-21, secreted by...

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Autors principals: Zotos, Dimitra, Coquet, Jonathan M., Zhang, Yang, Light, Amanda, D'Costa, Kathy, Kallies, Axel, Corcoran, Lynn M., Godfrey, Dale I., Toellner, Kai-Michael, Smyth, Mark J., Nutt, Stephen L., Tarlinton, David M.
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2010
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2822601/
https://ncbi.nlm.nih.gov/pubmed/20142430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20091777
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