Germinal center B cell development has distinctly regulated stages completed by disengagement from T cell help

To reconcile conflicting reports on the role of CD40 signaling in germinal center (GC) formation, we examined the earliest stages of murine GC B cell differentiation. Peri-follicular GC precursors first expressed intermediate levels of BCL6 while co-expressing the transcription factors RelB and IRF4...

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Enregistré dans:
Détails bibliographiques
Publié dans:eLife
Auteurs principaux: Zhang, Ting-ting, Gonzalez, David G, Cote, Christine M, Kerfoot, Steven M, Deng, Shaoli, Cheng, Yuqing, Magari, Masaki, Haberman, Ann M
Format: Artigo
Langue:Inglês
Publié: eLife Sciences Publications, Ltd 2017
Sujets:
Immunology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5429091/
https://ncbi.nlm.nih.gov/pubmed/28498098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.19552
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