Evidence for a protective role for the rs805305 single nucleotide polymorphism of dimethylarginine dimethylaminohydrolase 2 (DDAH2) in septic shock through the regulation of DDAH activity

BACKGROUND: Dimethylarginine dimethylaminohydrolase 2 (DDAH2) regulates the synthesis of nitric oxide (NO) through the metabolism of the endogenous inhibitor of nitric oxide synthase, asymmetric dimethylarginine (ADMA). Pilot studies have associated the rs805305 SNP of DDAH2 with ADMA concentrations...

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Detalhes bibliográficos
Publicado no:Crit Care
Main Authors: Lambden, Simon, Tomlinson, James, Piper, Sophie, Gordon, Anthony C., Leiper, James
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6288902/
https://ncbi.nlm.nih.gov/pubmed/30538005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13054-018-2277-5
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