Inhibitors of the Hydrolytic Enzyme Dimethylarginine Dimethylaminohydrolase (DDAH): Discovery, Synthesis and Development

Dimethylarginine dimethylaminohydrolase (DDAH) is a highly conserved hydrolytic enzyme found in numerous species, including bacteria, rodents, and humans. In humans, the DDAH-1 isoform is known to metabolize endogenous asymmetric dimethylarginine (ADMA) and monomethyl arginine (l-NMMA), with ADMA pr...

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Bibliographic Details
Published in:Molecules
Main Authors: Murphy, Rhys B., Tommasi, Sara, Lewis, Benjamin C., Mangoni, Arduino A.
Format: Artigo
Language:Inglês
Published: MDPI 2016
Subjects:
Review
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6273216/
https://ncbi.nlm.nih.gov/pubmed/27187323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules21050615
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