Human dimethylarginine dimethylaminohydrolase 1 inhibition by proton pump inhibitors and the cardiovascular risk marker asymmetric dimethylarginine: in vitro and in vivo significance

Proton pump inhibitor (PPI)-induced inhibition of dimethylarginine dimethylaminohydrolase 1 (DDAH1), with consequent accumulation of the nitric oxide synthase inhibitor asymmetric dimethylarginine (ADMA), might explain the increased cardiovascular risk with PPI use. However, uncertainty exists regar...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Tommasi, S., Elliot, D. J., Hulin, J. A., Lewis, B. C., McEvoy, M., Mangoni, A. A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5460274/
https://ncbi.nlm.nih.gov/pubmed/28588208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-03069-1
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