Allele-Level KIR Genotyping of More Than a Million Samples: Workflow, Algorithm, and Observations

The killer-cell immunoglobulin-like receptor (KIR) genes regulate natural killer cell activity, influencing predisposition to immune mediated disease, and affecting hematopoietic stem cell transplantation (HSCT) outcome. Owing to the complexity of the KIR locus, with extensive gene copy number varia...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Wagner, Ines, Schefzyk, Daniel, Pruschke, Jens, Schöfl, Gerhard, Schöne, Bianca, Gruber, Nicole, Lang, Kathrin, Hofmann, Jan, Gnahm, Christine, Heyn, Bianca, Marin, Wesley M., Dandekar, Ravi, Hollenbach, Jill A., Schetelig, Johannes, Pingel, Julia, Norman, Paul J., Sauter, Jürgen, Schmidt, Alexander H., Lange, Vinzenz
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6288436/
https://ncbi.nlm.nih.gov/pubmed/30564239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.02843
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