2.7 million samples genotyped for HLA by next generation sequencing: lessons learned

BACKGROUND: At the DKMS Life Science Lab, Next Generation Sequencing (NGS) has been used for ultra-high-volume high-resolution genotyping of HLA loci for the last three and a half years. Here, we report on our experiences in genotyping the HLA, CCR5, ABO, RHD and KIR genes using a direct amplicon se...

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Detalles Bibliográficos
Publicado en:BMC Genomics
Main Authors: Schöfl, Gerhard, Lang, Kathrin, Quenzel, Philipp, Böhme, Irina, Sauter, Jürgen, Hofmann, Jan A., Pingel, Julia, Schmidt, Alexander H., Lange, Vinzenz
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2017
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5309984/
https://ncbi.nlm.nih.gov/pubmed/28196473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12864-017-3575-z
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