Discovering de novo peptide substrates for enzymes using machine learning

The discovery of peptide substrates for enzymes with exclusive, selective activities is a central goal in chemical biology. In this paper, we develop a hybrid computational and biochemical method to rapidly optimize peptides for specific, orthogonal biochemical functions. The method is an iterative...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Tallorin, Lorillee, Wang, JiaLei, Kim, Woojoo E., Sahu, Swagat, Kosa, Nicolas M., Yang, Pu, Thompson, Matthew, Gilson, Michael K., Frazier, Peter I., Burkart, Michael D., Gianneschi, Nathan C.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6286390/
https://ncbi.nlm.nih.gov/pubmed/30531862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07717-6
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