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Serine proteinases in the turnover of the cartilage extracellular matrix in the joint: implications for therapeutics
Cartilage destruction is a key characteristic of arthritic disease, a process now widely established to be mediated by metzincins such as MMPs. Despite showing promise in preclinical trials during the 1990s, MMP inhibitors for the blockade of extracellular matrix turnover in the treatment of cancer...
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| Udgivet i: | Br J Pharmacol |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
John Wiley and Sons Inc.
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6284380/ https://ncbi.nlm.nih.gov/pubmed/29473950 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14173 |
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