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Serine proteinases in the turnover of the cartilage extracellular matrix in the joint: implications for therapeutics

Cartilage destruction is a key characteristic of arthritic disease, a process now widely established to be mediated by metzincins such as MMPs. Despite showing promise in preclinical trials during the 1990s, MMP inhibitors for the blockade of extracellular matrix turnover in the treatment of cancer...

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Publicat a:Br J Pharmacol
Autors principals: Wilkinson, David J, Arques, Maria del Carmen, Huesa, Carmen, Rowan, Andrew D
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2018
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6284380/
https://ncbi.nlm.nih.gov/pubmed/29473950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14173
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