Protein Modification by Deamidation Indicates Variations in Joint Extracellular Matrix Turnover

As extracellular proteins age, they undergo and accumulate nonenzymatic post-translational modifications that cannot be repaired. We hypothesized that these could be used to systemically monitor loss of extracellular matrix due to chronic arthritic diseases such as osteoarthritis (OA). To test this,...

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Detalhes bibliográficos
Main Authors: Catterall, Jonathan B., Hsueh, Ming F., Stabler, Thomas V., McCudden, Christopher R., Bolognesi, Michael, Zura, Robert, Jordan, Joanne M., Renner, Jordan B., Feng, Sheng, Kraus, Virginia B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Glycobiology and Extracellular Matrices
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3281605/
https://ncbi.nlm.nih.gov/pubmed/22179616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.249649
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