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The SARM1 Toll/Interleukin-1 Receptor (TIR) Domain Possesses Intrinsic NAD(+) Cleavage Activity that Promotes Pathological Axonal Degeneration

Axonal degeneration is an early and prominent feature of many neurological disorders. SARM1 is the central executioner of the axonal degeneration pathway that culminates in depletion of axonal NAD(+); yet the identity of the underlying NAD(+) depleting enzyme(s) is unknown. Here, in a series of expe...

Täydet tiedot

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Bibliografiset tiedot
Julkaisussa:Neuron
Päätekijät: Essuman, Kow, Summers, Daniel W., Sasaki, Yo, Mao, Xianrong, DiAntonio, Aaron, Milbrandt, Jeffrey
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2017
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6284238/
https://ncbi.nlm.nih.gov/pubmed/28334607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2017.02.022
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