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The SARM1 Toll/Interleukin-1 Receptor (TIR) Domain Possesses Intrinsic NAD(+) Cleavage Activity that Promotes Pathological Axonal Degeneration

Axonal degeneration is an early and prominent feature of many neurological disorders. SARM1 is the central executioner of the axonal degeneration pathway that culminates in depletion of axonal NAD(+); yet the identity of the underlying NAD(+) depleting enzyme(s) is unknown. Here, in a series of expe...

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Publicado en:Neuron
Autores principales: Essuman, Kow, Summers, Daniel W., Sasaki, Yo, Mao, Xianrong, DiAntonio, Aaron, Milbrandt, Jeffrey
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6284238/
https://ncbi.nlm.nih.gov/pubmed/28334607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2017.02.022
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