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The SARM1 Toll/Interleukin-1 Receptor (TIR) Domain Possesses Intrinsic NAD(+) Cleavage Activity that Promotes Pathological Axonal Degeneration
Axonal degeneration is an early and prominent feature of many neurological disorders. SARM1 is the central executioner of the axonal degeneration pathway that culminates in depletion of axonal NAD(+); yet the identity of the underlying NAD(+) depleting enzyme(s) is unknown. Here, in a series of expe...
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| Publicado en: | Neuron |
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| Autores principales: | , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2017
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6284238/ https://ncbi.nlm.nih.gov/pubmed/28334607 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2017.02.022 |
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