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TIR Domain Proteins Are an Ancient Family of NAD(+) Consuming Enzymes

The Toll/Interleukin-1 Receptor (TIR) domain is the signature-signaling domain of Toll-Like Receptors (TLRs) and their adaptors, serving as a scaffold for the assembly of protein complexes for innate immune signaling [1, 2]. TIR domain proteins are also expressed in plants, where they mediate diseas...

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Foilsithe in:Curr Biol
Main Authors: Essuman, Kow, Summers, Daniel W., Sasaki, Yo, Mao, Xianrong, Yim, Aldrin K.Y., DiAntonio, Aaron, Milbrandt, Jeffrey
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2018
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5802418/
https://ncbi.nlm.nih.gov/pubmed/29395922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2017.12.024
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