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Lysosome Membrane Permeabilization and Disruption of the Molecular Target of Rapamycin (mTOR)-Lysosome Interaction Are Associated with the Inhibition of Lung Cancer Cell Proliferation by a Chloroquinoline Analog

Lysosomes degrade cellular proteins and organelles and regulate cell signaling by providing a surface for the formation of critical protein complexes, notably molecular target of rapamycin (mTOR) complex 1 (mTORC1). Striking differences in the lysosomes of cancer versus normal cells suggest that the...

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Detaylı Bibliyografya
Yayımlandı:Mol Pharmacol
Asıl Yazarlar: Sironi, Juan, Aranda, Evelyn, Nordstrøm, Lars Ulrik, Schwartz, Edward L.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The American Society for Pharmacology and Experimental Therapeutics 2019
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6284226/
https://ncbi.nlm.nih.gov/pubmed/30409790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.118.113118
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