Rapamycin directly activates lysosomal mucolipin TRP channels independent of mTOR

Rapamycin (Rap) and its derivatives, called rapalogs, are being explored in clinical trials targeting cancer and neurodegeneration. The underlying mechanisms of Rap actions, however, are not well understood. Mechanistic target of rapamycin (mTOR), a lysosome-localized protein kinase that acts as a c...

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Pubblicato in:PLoS Biol
Autori principali: Zhang, Xiaoli, Chen, Wei, Gao, Qiong, Yang, Junsheng, Yan, Xueni, Zhao, Han, Su, Lin, Yang, Meimei, Gao, Chenlang, Yao, Yao, Inoki, Ken, Li, Dan, Shao, Rong, Wang, Shiyi, Sahoo, Nirakar, Kudo, Fumitaka, Eguchi, Tadashi, Ruan, Benfang, Xu, Haoxing
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2019
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6528971/
https://ncbi.nlm.nih.gov/pubmed/31112550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3000252
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