Rapamycin directly activates lysosomal mucolipin TRP channels independent of mTOR

Rapamycin (Rap) and its derivatives, called rapalogs, are being explored in clinical trials targeting cancer and neurodegeneration. The underlying mechanisms of Rap actions, however, are not well understood. Mechanistic target of rapamycin (mTOR), a lysosome-localized protein kinase that acts as a c...

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Detalhes bibliográficos
Publicado no:PLoS Biol
Main Authors: Zhang, Xiaoli, Chen, Wei, Gao, Qiong, Yang, Junsheng, Yan, Xueni, Zhao, Han, Su, Lin, Yang, Meimei, Gao, Chenlang, Yao, Yao, Inoki, Ken, Li, Dan, Shao, Rong, Wang, Shiyi, Sahoo, Nirakar, Kudo, Fumitaka, Eguchi, Tadashi, Ruan, Benfang, Xu, Haoxing
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6528971/
https://ncbi.nlm.nih.gov/pubmed/31112550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3000252
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