Rapamycin directly activates lysosomal mucolipin TRP channels independent of mTOR

Rapamycin (Rap) and its derivatives, called rapalogs, are being explored in clinical trials targeting cancer and neurodegeneration. The underlying mechanisms of Rap actions, however, are not well understood. Mechanistic target of rapamycin (mTOR), a lysosome-localized protein kinase that acts as a c...

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Bibliographic Details
Published in:PLoS Biol
Main Authors: Zhang, Xiaoli, Chen, Wei, Gao, Qiong, Yang, Junsheng, Yan, Xueni, Zhao, Han, Su, Lin, Yang, Meimei, Gao, Chenlang, Yao, Yao, Inoki, Ken, Li, Dan, Shao, Rong, Wang, Shiyi, Sahoo, Nirakar, Kudo, Fumitaka, Eguchi, Tadashi, Ruan, Benfang, Xu, Haoxing
Format: Artigo
Language:Inglês
Published: Public Library of Science 2019
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6528971/
https://ncbi.nlm.nih.gov/pubmed/31112550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3000252
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