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Rapamycin directly activates lysosomal mucolipin TRP channels independent of mTOR
Rapamycin (Rap) and its derivatives, called rapalogs, are being explored in clinical trials targeting cancer and neurodegeneration. The underlying mechanisms of Rap actions, however, are not well understood. Mechanistic target of rapamycin (mTOR), a lysosome-localized protein kinase that acts as a c...
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| Published in: | PLoS Biol |
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| Main Authors: | , , , , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Public Library of Science
2019
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6528971/ https://ncbi.nlm.nih.gov/pubmed/31112550 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3000252 |
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