Rapamycin directly activates lysosomal mucolipin TRP channels independent of mTOR

Rapamycin (Rap) and its derivatives, called rapalogs, are being explored in clinical trials targeting cancer and neurodegeneration. The underlying mechanisms of Rap actions, however, are not well understood. Mechanistic target of rapamycin (mTOR), a lysosome-localized protein kinase that acts as a c...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:PLoS Biol
Asıl Yazarlar: Zhang, Xiaoli, Chen, Wei, Gao, Qiong, Yang, Junsheng, Yan, Xueni, Zhao, Han, Su, Lin, Yang, Meimei, Gao, Chenlang, Yao, Yao, Inoki, Ken, Li, Dan, Shao, Rong, Wang, Shiyi, Sahoo, Nirakar, Kudo, Fumitaka, Eguchi, Tadashi, Ruan, Benfang, Xu, Haoxing
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2019
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6528971/
https://ncbi.nlm.nih.gov/pubmed/31112550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3000252
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