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A Molecular Mechanism to Regulate Lysosome Motility for Lysosome Positioning and Tubulation
To mediate the degradation of bio-macromolecules, lysosomes must traffic towards cargo-carrying vesicles for subsequent membrane fusion or fission. Mutations of the lysosomal Ca(2+) channel TRPML1 cause lysosome storage disease (LSD) characterized by disordered lysosomal membrane trafficking in cell...
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| izdano v: | Nat Cell Biol |
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| Main Authors: | , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2016
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4871318/ https://ncbi.nlm.nih.gov/pubmed/26950892 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3324 |
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