Up-regulation of lysosomal TRPML1 channels is essential for lysosomal adaptation to nutrient starvation

Upon nutrient starvation, autophagy digests unwanted cellular components to generate catabolites that are required for housekeeping biosynthesis processes. A complete execution of autophagy demands an enhancement in lysosome function and biogenesis to match the increase in autophagosome formation. H...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Proc Natl Acad Sci U S A
Egile Nagusiak: Wang, Wuyang, Gao, Qiong, Yang, Meimei, Zhang, Xiaoli, Yu, Lu, Lawas, Maria, Li, Xinran, Bryant-Genevier, Marthe, Southall, Noel T., Marugan, Juan, Ferrer, Marc, Xu, Haoxing
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2015
Gaiak:
PNAS Plus
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4371935/
https://ncbi.nlm.nih.gov/pubmed/25733853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1419669112
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