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Up-regulation of lysosomal TRPML1 channels is essential for lysosomal adaptation to nutrient starvation
Upon nutrient starvation, autophagy digests unwanted cellular components to generate catabolites that are required for housekeeping biosynthesis processes. A complete execution of autophagy demands an enhancement in lysosome function and biogenesis to match the increase in autophagosome formation. H...
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| Publié dans: | Proc Natl Acad Sci U S A |
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| Auteurs principaux: | , , , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4371935/ https://ncbi.nlm.nih.gov/pubmed/25733853 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1419669112 |
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