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Up-regulation of lysosomal TRPML1 channels is essential for lysosomal adaptation to nutrient starvation

Upon nutrient starvation, autophagy digests unwanted cellular components to generate catabolites that are required for housekeeping biosynthesis processes. A complete execution of autophagy demands an enhancement in lysosome function and biogenesis to match the increase in autophagosome formation. H...

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Библиографические подробности
Опубликовано в: :Proc Natl Acad Sci U S A
Главные авторы: Wang, Wuyang, Gao, Qiong, Yang, Meimei, Zhang, Xiaoli, Yu, Lu, Lawas, Maria, Li, Xinran, Bryant-Genevier, Marthe, Southall, Noel T., Marugan, Juan, Ferrer, Marc, Xu, Haoxing
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2015
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4371935/
https://ncbi.nlm.nih.gov/pubmed/25733853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1419669112
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