MCOLN1 is a ROS sensor in lysosomes that regulates autophagy

Cellular stresses trigger autophagy to remove damaged macromolecules and organelles. Lysosomes ‘host' multiple stress-sensing mechanisms that trigger the coordinated biogenesis of autophagosomes and lysosomes. For example, transcription factor (TF)EB, which regulates autophagy and lysosome biog...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Zhang, Xiaoli, Cheng, Xiping, Yu, Lu, Yang, Junsheng, Calvo, Raul, Patnaik, Samarjit, Hu, Xin, Gao, Qiong, Yang, Meimei, Lawas, Maria, Delling, Markus, Marugan, Juan, Ferrer, Marc, Xu, Haoxing
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4931332/
https://ncbi.nlm.nih.gov/pubmed/27357649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12109
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