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The endoplasmic reticulum, not the pH gradient, drives calcium refilling of lysosomes
Impaired homeostasis of lysosomal Ca(2+) causes lysosome dysfunction and lysosomal storage diseases (LSDs), but the mechanisms by which lysosomes acquire and refill Ca(2+) are not known. We developed a physiological assay to monitor lysosomal Ca(2+) store refilling using specific activators of lysos...
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| Pubblicato in: | eLife |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
eLife Sciences Publications, Ltd
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4909396/ https://ncbi.nlm.nih.gov/pubmed/27213518 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.15887 |
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