The endoplasmic reticulum, not the pH gradient, drives calcium refilling of lysosomes

Impaired homeostasis of lysosomal Ca(2+) causes lysosome dysfunction and lysosomal storage diseases (LSDs), but the mechanisms by which lysosomes acquire and refill Ca(2+) are not known. We developed a physiological assay to monitor lysosomal Ca(2+) store refilling using specific activators of lysos...

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Bibliografische gegevens
Gepubliceerd in:eLife
Hoofdauteurs: Garrity, Abigail G, Wang, Wuyang, Collier, Crystal MD, Levey, Sara A, Gao, Qiong, Xu, Haoxing
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: eLife Sciences Publications, Ltd 2016
Onderwerpen:
Cell Biology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4909396/
https://ncbi.nlm.nih.gov/pubmed/27213518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.15887
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