Identification and binding mode of a novel Leishmania Trypanothione reductase inhibitor from high throughput screening

Trypanothione reductase (TR) is considered to be one of the best targets to find new drugs against Leishmaniasis. This enzyme is fundamental for parasite survival in the host since it reduces trypanothione, a molecule used by the tryparedoxin/tryparedoxin peroxidase system of Leishmania to neutraliz...

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Detaylı Bibliyografya
Yayımlandı:PLoS Negl Trop Dis
Asıl Yazarlar: Turcano, Lorenzo, Torrente, Esther, Missineo, Antonino, Andreini, Matteo, Gramiccia, Marina, Di Muccio, Trentina, Genovese, Ilaria, Fiorillo, Annarita, Harper, Steven, Bresciani, Alberto, Colotti, Gianni, Ilari, Andrea
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2018
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6283646/
https://ncbi.nlm.nih.gov/pubmed/30475811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0006969
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