Spiro-containing derivatives show antiparasitic activity against Trypanosoma brucei through inhibition of the trypanothione reductase enzyme

Trypanothione reductase (TR) is a key enzyme that catalyzes the reduction of trypanothione, an antioxidant dithiol that protects Trypanosomatid parasites from oxidative stress induced by mammalian host defense systems. TR is considered an attractive target for the development of novel anti-parasitic...

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Detalhes bibliográficos
Publicado no:PLoS Negl Trop Dis
Main Authors: Turcano, Lorenzo, Battista, Theo, De Haro, Esther Torrente, Missineo, Antonino, Alli, Cristina, Paonessa, Giacomo, Colotti, Gianni, Harper, Steven, Fiorillo, Annarita, Ilari, Andrea, Bresciani, Alberto
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7269337/
https://ncbi.nlm.nih.gov/pubmed/32437349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0008339
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