Spiro-containing derivatives show antiparasitic activity against Trypanosoma brucei through inhibition of the trypanothione reductase enzyme

Trypanothione reductase (TR) is a key enzyme that catalyzes the reduction of trypanothione, an antioxidant dithiol that protects Trypanosomatid parasites from oxidative stress induced by mammalian host defense systems. TR is considered an attractive target for the development of novel anti-parasitic...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:PLoS Negl Trop Dis
Egile Nagusiak: Turcano, Lorenzo, Battista, Theo, De Haro, Esther Torrente, Missineo, Antonino, Alli, Cristina, Paonessa, Giacomo, Colotti, Gianni, Harper, Steven, Fiorillo, Annarita, Ilari, Andrea, Bresciani, Alberto
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2020
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7269337/
https://ncbi.nlm.nih.gov/pubmed/32437349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0008339
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