The structure of the RbBP5 β-propeller domain reveals a surface with potential nucleic acid binding sites

The multi-protein complex WRAD, formed by WDR5, RbBP5, Ash2L and Dpy30, binds to the MLL SET domain to stabilize the catalytically active conformation required for histone H3K4 methylation. In addition, the WRAD complex contributes to the targeting of the activated complex to specific sites on chrom...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nucleic Acids Res
Prif Awduron: Mittal, Anshumali, Hobor, Fruzsina, Zhang, Ying, Martin, Stephen R, Gamblin, Steven J, Ramos, Andres, Wilson, Jon R
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2018
Pynciau:
Structural Biology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6283417/
https://ncbi.nlm.nih.gov/pubmed/29897600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky199
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