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A phosphorylation switch on RbBP5 regulates histone H3 Lys4 methylation
The methyltransferase activity of the trithorax group (TrxG) protein MLL1 found within its COMPASS (complex associated with SET1)-like complex is allosterically regulated by a four-subunit complex composed of WDR5, RbBP5, Ash2L, and DPY30 (also referred to as WRAD). We report structural evidence sho...
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| Publié dans: | Genes Dev |
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| Auteurs principaux: | , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Cold Spring Harbor Laboratory Press
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4298132/ https://ncbi.nlm.nih.gov/pubmed/25593305 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.254870.114 |
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