A phosphorylation switch on RbBP5 regulates histone H3 Lys4 methylation

The methyltransferase activity of the trithorax group (TrxG) protein MLL1 found within its COMPASS (complex associated with SET1)-like complex is allosterically regulated by a four-subunit complex composed of WDR5, RbBP5, Ash2L, and DPY30 (also referred to as WRAD). We report structural evidence sho...

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Dettagli Bibliografici
Pubblicato in:Genes Dev
Autori principali: Zhang, Pamela, Chaturvedi, Chandra-Prakash, Tremblay, Veronique, Cramet, Myriam, Brunzelle, Joseph S., Skiniotis, Georgios, Brand, Marjorie, Shilatifard, Ali, Couture, Jean-François
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2015
Soggetti:
Research Communication
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4298132/
https://ncbi.nlm.nih.gov/pubmed/25593305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.254870.114
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