A non-active site SET domain surface crucial for the interaction of MLL1 and the RbBP5-ASH2L heterodimer within MLL family core complexes

The Mixed Lineage Leukemia-1 (MLL1) enzyme is a histone H3 lysine 4 (H3K4) monomethyltransferase and has served as a paradigm for understanding the mechanism of action of the human SET1 family of enzymes that include MLL1–4, and SET1d1a,b. Dimethylation of H3K4 requires a sub-complex including WDR5,...

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Hauptverfasser: Shinsky, Stephen A., Hu, Michael, Vought, Valarie E., Ng, Sarah B., Bamshad, Michael J., Shendure, Jay, Cosgrove, Michael S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4066448/
https://ncbi.nlm.nih.gov/pubmed/24680668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2014.03.011
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