A non-active site SET domain surface crucial for the interaction of MLL1 and the RbBP5-ASH2L heterodimer within MLL family core complexes

The Mixed Lineage Leukemia-1 (MLL1) enzyme is a histone H3 lysine 4 (H3K4) monomethyltransferase and has served as a paradigm for understanding the mechanism of action of the human SET1 family of enzymes that include MLL1–4, and SET1d1a,b. Dimethylation of H3K4 requires a sub-complex including WDR5,...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Shinsky, Stephen A., Hu, Michael, Vought, Valarie E., Ng, Sarah B., Bamshad, Michael J., Shendure, Jay, Cosgrove, Michael S.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2014
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4066448/
https://ncbi.nlm.nih.gov/pubmed/24680668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2014.03.011
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak