An Ash2L/RbBP5 Heterodimer Stimulates the MLL1 Methyltransferase Activity through Coordinated Substrate Interactions with the MLL1 SET Domain

Histone H3 lysine 4 (K4) methylation is a prevalent mark associated with transcription activation and is mainly catalyzed by the MLL/SET1 family histone methyltransferases. A common feature of the mammalian MLL/SET1 complexes is the presence of three core components (RbBP5, Ash2L and WDR5) and a cat...

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Autors principals: Cao, Fang, Chen, Yong, Cierpicki, Tomasz, Liu, Yifan, Basrur, Venkatesha, Lei, Ming, Dou, Yali
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2010
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2990719/
https://ncbi.nlm.nih.gov/pubmed/21124902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0014102
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