The internal interaction in RBBP5 regulates assembly and activity of MLL1 methyltransferase complex

The Mixed Lineage Leukemia protein 1 (MLL1) plays an essential role in the maintenance of the histone H3 lysine 4 (H3K4) methylation status for gene expression during differentiation and development. The methyltransferase activity of MLL1 is regulated by three conserved core subunits, WDR5, RBBP5 an...

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Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Han, Jianming, Li, Tingting, Li, Yanjing, Li, Muchun, Wang, Xiaoman, Peng, Chao, Su, Chen, Li, Na, Li, Yiwen, Xu, Ying, Chen, Yong
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2019
Schlagworte:
Structural Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6821195/
https://ncbi.nlm.nih.gov/pubmed/31544921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz819
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