IMPDH2 promotes colorectal cancer progression through activation of the PI3K/AKT/mTOR and PI3K/AKT/FOXO1 signaling pathways

BACKGROUND: Inosine 5′-monophosphate dehydrogenase type II (IMPDH2) was originally identified as an oncogene in several human cancers. However, the clinical significance and biological role of IMPDH2 remain poorly understood in colorectal cancer (CRC). METHODS: Quantitative real-time polymerase chai...

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Detalhes bibliográficos
Publicado no:J Exp Clin Cancer Res
Main Authors: Duan, Shiyu, Huang, Wenqing, Liu, Xiaoting, Liu, Xuming, Chen, Nana, Xu, Qiong, Hu, Yukun, Song, Wen, Zhou, Jun
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6282329/
https://ncbi.nlm.nih.gov/pubmed/30518405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-018-0980-3
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