NF1 mutations are recurrent in adult acute myeloid leukemia and confer poor outcome

Targeted mutation assessment of 81 genes in 1,021 adults with de novo acute myeloid leukemia (AML) identified recurrent mutations in the neurofibromin 1 (NF1) gene in 52 (5.1%) patients, including 36 (5.2%) younger and 16 (4.8%) older patients, which suggests NF1 belongs to the 20 most frequently mu...

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Bibliographic Details
Published in:Leukemia
Main Authors: Eisfeld, Ann-Kathrin, Kohlschmidt, Jessica, Mrózek, Krzysztof, Mims, Alice, Walker, Christopher J., Blachly, James S., Nicolet, Deedra, Orwick, Shelley, Maharry, Sophia E., Carroll, Andrew J., Powell, Bayard L., Kolitz, Jonathan E., Wang, Eunice S., Stone, Richard M., de la Chapelle, Albert, Byrd, John C., Bloomfield, Clara D.
Format: Artigo
Language:Inglês
Published: 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6281863/
https://ncbi.nlm.nih.gov/pubmed/29872168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41375-018-0147-4
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