Long-read sequencing technology indicates genome-wide effects of non-B DNA on polymerization speed and error rate

DNA conformation may deviate from the classical B-form in ∼13% of the human genome. Non-B DNA regulates many cellular processes; however, its effects on DNA polymerization speed and accuracy have not been investigated genome-wide. Such an inquiry is critical for understanding neurological diseases a...

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Bibliografiske detaljer
Udgivet i:Genome Res
Main Authors: Guiblet, Wilfried M., Cremona, Marzia A., Cechova, Monika, Harris, Robert S., Kejnovská, Iva, Kejnovsky, Eduard, Eckert, Kristin, Chiaromonte, Francesca, Makova, Kateryna D.
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2018
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6280752/
https://ncbi.nlm.nih.gov/pubmed/30401733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.241257.118
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