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Molecular mechanism of a covalent allosteric inhibitor of SUMO E1 activating enzyme
E1 enzymes activate ubiquitin (Ub) and ubiquitin-like modifiers (Ubls) in the first step of Ub/Ubl conjugation cascades and represent potential targets for therapeutic intervention in cancer and other life-threatening diseases. Here, we report the crystal structure of the E1 enzyme for the Ubl SUMO...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6279746/ https://ncbi.nlm.nih.gov/pubmed/30514846 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07015-1 |
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