Allosteric Inhibition of Ubiquitin-like Modifications by a Class of Inhibitor of SUMO-Activating Enzyme

Ubiquitin-like (Ubl) posttranslational modifications are potential targets of therapeutics. However, the only known mechanism for inhibiting a Ubl activating enzyme is through targeting its ATP-binding site. Here we identify an allosteric inhibitory site in the small ubiquitin-like modifier (SUMO) a...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Cell Chem Biol
Autors principals: Li, Yi-Jia, Du, Li, Wang, Jianghai, Vega, Ramir, Lee, Terry D., Miao, Yunan, Aldana-Masangkay, Grace, Samuels, Eric R., Li, Baozong, Ouyang, S. Xiaohu, Colayco, Sharon A., Bobkova, Ekaterina V., Divlianska, Daniela B., Sergienko, Eduard, Chung, Thomas D.Y., Fakih, Marwan, Chen, Yuan
Format: Artigo
Idioma:Inglês
Publicat: 2018
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6524651/
https://ncbi.nlm.nih.gov/pubmed/30581133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2018.10.026
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars