Allosteric Inhibition of Ubiquitin-like Modifications by a Class of Inhibitor of SUMO-Activating Enzyme

Ubiquitin-like (Ubl) posttranslational modifications are potential targets of therapeutics. However, the only known mechanism for inhibiting a Ubl activating enzyme is through targeting its ATP-binding site. Here we identify an allosteric inhibitory site in the small ubiquitin-like modifier (SUMO) a...

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Veröffentlicht in:Cell Chem Biol
Hauptverfasser: Li, Yi-Jia, Du, Li, Wang, Jianghai, Vega, Ramir, Lee, Terry D., Miao, Yunan, Aldana-Masangkay, Grace, Samuels, Eric R., Li, Baozong, Ouyang, S. Xiaohu, Colayco, Sharon A., Bobkova, Ekaterina V., Divlianska, Daniela B., Sergienko, Eduard, Chung, Thomas D.Y., Fakih, Marwan, Chen, Yuan
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6524651/
https://ncbi.nlm.nih.gov/pubmed/30581133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2018.10.026
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