Design of High Throughput Screening Assays and Identification of a SUMO1-Specific Small Molecule Chemotype Targeting the SUMO-Interacting Motif-Binding Surface

Protein-protein interactions are generally challenging to target by small molecules. To address the challenge, we have used a multi-disciplinary approach to identify small-molecule disruptors of protein-protein interactions that are mediated by SUMO (Small Ubiquitin-like MOdifier) proteins. SUMO mod...

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Publicado no:ACS Comb Sci
Main Authors: Alontaga, Aileen Y., Li, Yifei, Chen, Chih-Hong, Ma, Chen-Ting, Malany, Siobhan, Key, Danielle E., Sergienko, Eduard, Sun, Qing, Whipple, David A., Matharu, Daljit S., Li, Baozong, Vega, Ramir, Li, Yi-Jia, Schoenen, Frank J., Blagg, Brian S. J., Chung, Thomas D.Y., Chen, Yuan
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4609574/
https://ncbi.nlm.nih.gov/pubmed/25719760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/co500181b
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