Molecular mechanism of a covalent allosteric inhibitor of SUMO E1 activating enzyme

E1 enzymes activate ubiquitin (Ub) and ubiquitin-like modifiers (Ubls) in the first step of Ub/Ubl conjugation cascades and represent potential targets for therapeutic intervention in cancer and other life-threatening diseases. Here, we report the crystal structure of the E1 enzyme for the Ubl SUMO...

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Bibliografske podrobnosti
izdano v:Nat Commun
Main Authors: Lv, Zongyang, Yuan, Lingmin, Atkison, James H., Williams, Katelyn M., Vega, Ramir, Sessions, E. Hampton, Divlianska, Daniela B., Davies, Christopher, Chen, Yuan, Olsen, Shaun K.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2018
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6279746/
https://ncbi.nlm.nih.gov/pubmed/30514846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07015-1
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