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Crystal structure of a human ubiquitin E1–ubiquitin complex reveals conserved functional elements essential for activity
Ubiquitin (Ub) signaling plays a key regulatory role in nearly every aspect of eukaryotic biology and is initiated by E1 enzymes that activate and transfer Ub to E2 Ub-conjugating enzymes. Despite Ub E1's fundamental importance to the cell and its attractiveness as a target for therapeutic inte...
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| Udgivet i: | J Biol Chem |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6254350/ https://ncbi.nlm.nih.gov/pubmed/30279270 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.003975 |
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