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Crystal structure of a human ubiquitin E1–ubiquitin complex reveals conserved functional elements essential for activity

Ubiquitin (Ub) signaling plays a key regulatory role in nearly every aspect of eukaryotic biology and is initiated by E1 enzymes that activate and transfer Ub to E2 Ub-conjugating enzymes. Despite Ub E1's fundamental importance to the cell and its attractiveness as a target for therapeutic inte...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:J Biol Chem
मुख्य लेखकों: Lv, Zongyang, Williams, Katelyn M., Yuan, Lingmin, Atkison, James H., Olsen, Shaun K.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Society for Biochemistry and Molecular Biology 2018
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC6254350/
https://ncbi.nlm.nih.gov/pubmed/30279270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.003975
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