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Structural insights into the mechanism and E2 specificity of the RBR E3 ubiquitin ligase HHARI
RING-in-between-RING (RBR) ubiquitin (Ub) E3 ligases function with Ub E2s through a RING/HECT hybrid mechanism to conjugate Ub to target proteins. Here, we report the crystal structure of the RBR E3, HHARI, in complex with a UbcH7 ~ Ub thioester mimetic which reveals the molecular basis for the spec...
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| Udgivet i: | Nat Commun |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group UK
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5548887/ https://ncbi.nlm.nih.gov/pubmed/28790309 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00272-6 |
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