Macroscopic and Microscopic Activation of α7 Nicotinic Acetylcholine Receptors by the Structurally Unrelated Allosteric Agonist-Positive Allosteric Modulators (ago-PAMs) B-973B and GAT107

B-973 is an efficacious type II positive allosteric modulator (PAM) of α7 nicotinic acetylcholine receptors that, like 4BP-TQS and its active isomer GAT107, can produce direct allosteric activation in addition to potentiation of orthosteric agonist activity, which identifies it as an allosteric acti...

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Vydáno v:Mol Pharmacol
Hlavní autoři: Quadri, Marta, Garai, Sumanta, Thakur, Ganesh A., Stokes, Clare, Gulsevin, Alican, Horenstein, Nicole A., Papke, Roger L.
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Pharmacology and Experimental Therapeutics 2019
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6277926/
https://ncbi.nlm.nih.gov/pubmed/30348894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.118.113340
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