Molecular basis for activation of lecithin:cholesterol acyltransferase by a compound that increases HDL cholesterol

Lecithin:cholesterol acyltransferase (LCAT) and LCAT-activating compounds are being investigated as treatments for coronary heart disease (CHD) and familial LCAT deficiency (FLD). Herein we report the crystal structure of human LCAT in complex with a potent piperidinylpyrazolopyridine activator and...

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Dades bibliogràfiques
Publicat a:eLife
Autors principals: Manthei, Kelly A, Yang, Shyh-Ming, Baljinnyam, Bolormaa, Chang, Louise, Glukhova, Alisa, Yuan, Wenmin, Freeman, Lita A, Maloney, David J, Schwendeman, Anna, Remaley, Alan T, Jadhav, Ajit, Tesmer, John JG
Format: Artigo
Idioma:Inglês
Publicat: eLife Sciences Publications, Ltd 2018
Matèries:
Biochemistry and Chemical Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6277198/
https://ncbi.nlm.nih.gov/pubmed/30479275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.41604
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