Structural analysis of lecithin:cholesterol acyltransferase bound to high density lipoprotein particles

Lecithin:cholesterol acyltransferase (LCAT) catalyzes a critical step of reverse cholesterol transport by esterifying cholesterol in high density lipoprotein (HDL) particles. LCAT is activated by apolipoprotein A-I (ApoA-I), which forms a double belt around HDL, however the manner in which LCAT enga...

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Udgivet i:Commun Biol
Main Authors: Manthei, Kelly A., Patra, Dhabaleswar, Wilson, Christopher J., Fawaz, Maria V., Piersimoni, Lolita, Shenkar, Jenny Capua, Yuan, Wenmin, Andrews, Philip C., Engen, John R., Schwendeman, Anna, Ohi, Melanie D., Tesmer, John J. G.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6962161/
https://ncbi.nlm.nih.gov/pubmed/31942029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-019-0749-z
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