Lecithin:Cholesterol Acyltransferase Activation by Sulfhydryl-Reactive Small Molecules: Role of Cysteine-31

Lecithin:cholesterol acyltransferase (LCAT) catalyzes plasma cholesteryl ester formation and is defective in familial lecithin:cholesterol acyltransferase deficiency (FLD), an autosomal recessive disorder characterized by low high-density lipoprotein, anemia, and renal disease. This study aimed to i...

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Detalhes bibliográficos
Publicado no:J Pharmacol Exp Ther
Main Authors: Freeman, Lita A., Demosky, Stephen J., Konaklieva, Monika, Kuskovsky, Rostislav, Aponte, Angel, Ossoli, Alice F., Gordon, Scott M., Koby, Ross F., Manthei, Kelly A., Shen, Min, Vaisman, Boris L., Shamburek, Robert D., Jadhav, Ajit, Calabresi, Laura, Gucek, Marjan, Tesmer, John J.G., Levine, Rodney L., Remaley, Alan T.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2017
Assuntos:
Drug Discovery and Translational Medicine
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5510151/
https://ncbi.nlm.nih.gov/pubmed/28576974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.117.240457
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